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HEALTH EFFECTS|DEVELOPMENTAL TOXICANTS
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DEVELOPMENTAL TOXICANTS
Developmental toxicants are agents that cause adverse effects on the developing child. Effects can include birth defects, low birth weight, biological dysfunctions, or psychological or behavioral deficits that become manifest as the child grows. Maternal exposure to toxic chemicals during pregnancy can disrupt the development or even cause the death of the fetus. Exposure of pregnant women to mercury, lowers birth weight and can cause severe brain damage in children. While developmental toxicity usually results from prenatal exposures to toxicants experienced by the
mother, it can also result from paternal exposures. For example, the occupational exposure of men to vinyl chloride has been associated with increased rates of spontaneous abortion in their wives. Early postnatal contact with toxicants can also affect normal development. Exposure to secondhand tobacco smoke, for example, increases an infant's risk of contracting respiratory infections or succumbing to sudden infant death syndrome.
References used to compile the list of Developmental Toxicants
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Suspected Developmental Toxicants
Note: For your convenience, these data are also available as a CSV file. Click here to download.
| Chemical Name |
CAS Registry Number (or EDF Substance ID) |
Reference(s) |
| (2AE,4E,8E)-(5'S,6S,6'R,7S,11R,13S,15S,17AR,20R,20AR,20BS)-6'-((S- )-SEC-BUTYL)-5',6,6',7,10,11,14,15,17A,20,20A,20B-DODECAHYDRO-20,- 20B-DIHYDROXY-5',6,8,19-TETRAMETHYL-17-OXOSPIRO(11,15-METHANO-2H,- 13H,17H-FURO(4,3,2-PQ)(2,6)BENZODIOXACYCLOOCTADEC[... | 65195-55-3 | P65-PEND |
| 1,1,1-TRICHLOROETHANE | 71-55-6 | EPA-SARA |
| 1,1,2,2-TETRACHLOROETHANE | 79-34-5 | EPA-SARA |
| 1,1-DICHLOROETHYLENE | 75-35-4 | EPA-SARA, JANK |
| 1,2,4-TRICHLOROBENZENE | 120-82-1 | EPA-SARA |
| 1,2-BENZENEDICARBOXYLIC ACID, DI-C8- 10-BRANCHED ALKYL ESTERS, C9-RICH | 68515-48-0 | CERHR |
| 1,2-BENZENEDICARBOXYLIC ACID, DI-C9- 11-BRANCHED ALKYL ESTERS, C10-RICH | 68515-49-1 | CERHR |
| 1,2-BENZENEDICARBOXYLIC ACID, DIISODECYL ESTER | 26761-40-0 | CERHR, P65-CAND |
| 1,2-BENZENEDICARBOXYLIC ACID, DIISONONYL ESTER | 28553-12-0 | CERHR |
| 1,2-DIBROMO-3-CHLOROPROPANE (DBCP) | 96-12-8 | EPA-SARA |
| 1,2-DICHLOROETHANE | 107-06-2 | EPA-SARA |
| 1,2-ETHANEDIAMINE, N,N'-BIS(2-AMINOETHYL)- | 112-24-3 | JANK |
| 1,3-DIMETHYLUREA | 96-31-1 | JANK |
| 1,4-DICHLOROBENZENE | 106-46-7 | ATSDR, JANK |
| 1-BROMOPROPANE | 106-94-5 | P65-CAND |
| 1-HEXANOL, 2-ETHYL- | 104-76-7 | JANK |
| 1-HYDROXY-2-PHENOXYETHANE | 122-99-6 | NTP-R |
| 2,4-D | 94-75-7 | EPA-SARA |
| 2,4-D 2-ETHYL-4-METHYLPENTYL ESTER | 53404-37-8 | EPA-TRI |
| 2,4-D 2-ETHYLHEXYL ESTER | 1928-43-4 | EPA-TRI |
| 2,4-D BUTYL ESTER | 94-80-4 | JANK |
| 2,4-D, ISOOCTYL ESTER | 25168-26-7 | JANK |
| 2,4-DB | 94-82-6 | EPA-TRI, P65-CAND |
| 2,4-DINITROPHENOL | 51-28-5 | EPA-SARA |
| 2,4-DP | 120-36-5 | EPA-TRI, JANK, P65-PEND |
| 2-CHLOR-1,3-BUTADIENE | 126-99-8 | EPA-SARA |
| 2-METHOXYPROPYL-1-ACETATE | 70657-70-4 | JANK |
| 2-NITROPROPANE | 79-46-9 | EPA-SARA |
| 2-PHENYLPHENOL | 90-43-7 | EPA-SARA |
| ABAMECTIN | 71751-41-2 | EPA-TRI, P65-PEND |
| ACETALDEHYDE | 75-07-0 | JANK |
| ACETIC ACID, INDOLYL- | 87-51-4 | JANK |
| ACETONITRILE | 75-05-8 | EPA-SARA, JANK |
| ACROLEIN | 107-02-8 | JANK |
| ACRYLONITRILE | 107-13-1 | ATSDR, EPA-SARA |
| ALACHLOR | 15972-60-8 | EPA-TRI |
| ALBUTEROL | 18559-94-9 | P65-CAND |
| ALDRIN | 309-00-2 | ATSDR, EPA-SARA, JANK |
| ALKANES, CHLORO | 61788-76-9 | P65-MC |
| ALLYL CHLORIDE | 107-05-1 | EPA-SARA |
| AMINONICOTINAMIDE | 329-89-5 | JANK |
| AMITROLE | 61-82-5 | JANK |
| ANILAZINE | 101-05-3 | EPA-TRI |
| AROMATIC NAPHTHA, TYPE I | 64742-95-6 | JANK |
| ARSENIC (ORGANIC OR INORGANIC COMPOUNDS) | ARF750 | OEHHA-CREL, P65-MC |
| ARSENIC COMPOUNDS | ARF-750 | OEHHA-CREL |
| ATORVASTATIN CALCIUM | 134523-03-8 | P65-CAND |
| BAPN | 151-18-8 | JANK |
| BAPN FUMARATE | 2079-89-2 | JANK |
| BARIUM | 7440-39-3 | EPA-SARA |
| BENZO(A)PYRENE | 50-32-8 | JANK, P65-PEND |
| BENZOIC TRICHLORIDE | 98-07-7 | EPA-SARA |
| BENZOYL CHLORIDE | 98-88-4 | EPA-SARA |
| BENZYL BUTYL PHTHALATE | 85-68-7 | CERHR, P65-CAND |
| BENZYL CHLORIDE | 100-44-7 | EPA-SARA |
| BIPHENYL | 92-52-4 | EPA-SARA |
| BIS(TRIBUTYLTIN) OXIDE | 56-35-9 | JANK |
| BORON | 7440-42-8 | ATSDR |
| BROMINE COMPOUNDS (ORGANIC OR INORGANIC) | EDF-227 | P65-MC |
| CACODYLIC ACID | 75-60-5 | JANK |
| CADMIUM CHLORIDE | 10108-64-2 | JANK |
| CADMIUM COMPOUNDS | CAE750 | JANK, P65-MC |
| CAMPHECHLOR | 8001-35-2 | EPA-SARA, JANK |
| CAPTAN | 133-06-2 | EPA-SARA, JANK |
| CARBARYL | 63-25-2 | EPA-SARA, JANK |
| CARBON DIOXIDE | 124-38-9 | JANK |
| CARBON TETRACHLORIDE | 56-23-5 | EPA-SARA, OEHHA-AREL, OEHHA-CREL |
| CESIUM | 7440-46-2 | ATSDR |
| CHLORAMPHENICOL | 56-75-7 | JANK |
| CHLORDANE | 57-74-9 | ATSDR, EPA-SARA |
| CHLORINE DIOXIDE | 10049-04-4 | EPA-SARA, JANK |
| CHLOROBENZENE | 108-90-7 | JANK |
| CHLORODIFLUOROMETHANE | 75-45-6 | OEHHA-CREL |
| CHLOROETHANE | 75-00-3 | ATSDR, OEHHA-CREL |
| CHLOROFORM | 67-66-3 | EPA-SARA, JANK, OEHHA-AREL, OEHHA-CREL |
| COBALT | 7440-48-4 | ATSDR |
| COPPER | 7440-50-8 | EPA-SARA |
| CYANIDE | 57-12-5 | EPA-SARA |
| CYCLOHEXANONE | 108-94-1 | JANK |
| DDT (TOTAL) | EDF-229 | P65-MC |
| DECABROMODIPHENYL OXIDE | 1163-19-5 | EPA-SARA |
| DELTA-8,9-ISOMER OF AVERMECTIN | EDF-376 | P65-PEND |
| DIAMINOTOLUENE (MIXED ISOMERS) | 25376-45-8 | JANK |
| DIAZINON | 333-41-5 | EPA-TRI, JANK |
| DIBENZOFURANS (CHLORINATED) | 1080 | OEHHA-CREL |
| DIBUTYL PHTHALATE | 84-74-2 | ATSDR, CERHR, EPA-SARA, JANK, NTP-R, P65-CAND |
| DICAMBA | 1918-00-9 | EPA-TRI |
| DICHLORVOS | 62-73-7 | EPA-SARA, JANK |
| DIETHYLENE GLYCOL DIMETHYL ETHER | 111-96-6 | JANK |
| DIETHYLENE GLYCOL ETHER | 111-46-6 | JANK |
| DIETHYLENE GLYCOL MONOMETHYL ETHER | 111-77-3 | JANK |
| DIMETHOATE | 60-51-5 | EPA-TRI, JANK |
| DIMETHYL CHLOROTHIOPHOSPHATE | 2524-03-0 | EPA-TRI |
| DIMETHYLAMINE DICAMBA | 2300-66-5 | EPA-TRI |
| DIOXIN AND DIOXIN-LIKE COMPOUNDS | EDF-018 | P65-MC |
| DIPHENYL-P-PHENYLENEDIAMINE | 74-31-7 | JANK |
| DIRECT BLUE 6 | 2602-46-2 | EPA-SARA |
| DISODIUM HYDROGEN ARSENATE | 7778-43-0 | OEHHA-CREL |
| DISULFIRAM | 97-77-8 | JANK |
| DISULFOTON | 298-04-4 | ATSDR |
| DIURON | 330-54-1 | EPA-TRI |
| EK 7011 | 123-39-7 | JANK |
| ERGOCALCIFEROL | 50-14-6 | JANK |
| ETHANOL | 64-17-5 | JANK |
| ETHYL ACRYLATE | 140-88-5 | EPA-SARA |
| ETHYLBENZENE | 100-41-4 | ATSDR, EPA-SARA, OEHHA-CREL |
| ETHYLENE GLYCOL | 107-21-1 | ATSDR, NTP-R, OEHHA-CREL |
| ETHYLENE GLYCOL DIETHYL ETHER | 629-14-1 | JANK |
| ETHYLENE GLYCOL DIMETHYL ETHER | 110-71-4 | JANK |
| ETHYLENE GLYCOL MONOBUTYL ETHER | 111-76-2 | JANK |
| ETHYLENE GLYCOL MONOPROPYL ETHER | 2807-30-9 | JANK |
| ETHYLENE OXIDE | 75-21-8 | EPA-SARA, JANK |
| FELODIPINE | 72509-76-3 | P65-CAND |
| FENBUTATIN OXIDE | 13356-08-6 | EPA-TRI, P65-PEND |
| FENOXYCARB | 72490-01-8 | EPA-TRI |
| FERBAM | 14484-64-1 | JANK |
| FLUOXETINE | 54910-89-3 | CERHR |
| FLUOXETINE HYDROCHLORIDE | 59333-67-4 | CERHR |
| FLUVASTATIN SODIUM | EDF-004 | P65-CAND |
| FOLPET | 133-07-3 | JANK |
| GAMMA-LINDANE | 58-89-9 | ATSDR, EPA-SARA |
| GLUTARALDHYDE | 111-30-8 | JANK |
| GLYCOL ETHERS | EDF-109 | P65-MC |
| GRISEOFULVIN | 126-07-8 | JANK |
| HEAVY METALS | EDF-380 | P65-MC |
| HEXACHLORO-1,3-BUTADIENE | 87-68-3 | EPA-SARA, JANK |
| HEXACHLOROCYCLOPENTADIENE | 77-47-4 | EPA-SARA |
| HEXACHLOROETHANE | 67-72-1 | EPA-SARA |
| HEXACHLOROPHENE (HCP) | 70-30-4 | JANK |
| HYDRAZINE | 302-01-2 | JANK |
| HYDROFLUORIC ACID | 7664-39-3 | EPA-SARA |
| IMAZALIL | 35554-44-0 | EPA-TRI, JANK |
| IMIDAN | 732-11-6 | JANK |
| INORGANIC BROMINE COMPOUNDS | EDF-015 | P65-MC |
| ISOPHORONE | 78-59-1 | OEHHA-CREL |
| ISOPROPYL ALCOHOL | 67-63-0 | OEHHA-CREL |
| LEWISITE (ARSENIC COMPOUND) | 541-25-3 | JANK |
| M-XYLENE | 108-38-3 | EPA-SARA, JANK |
| MANEB | 12427-38-2 | EPA-SARA, JANK |
| METALS | EDF-035 | P65-MC |
| METHANAMINE, N-METHYL-N-NITROSO | 62-75-9 | JANK |
| METHANOL | 67-56-1 | CERHR, JANK, OEHHA-CREL |
| METHOXYCHLOR | 72-43-5 | EPA-HEN, EPA-SARA |
| METHOXYFLURANE | 76-38-0 | JANK |
| METHYL ETHYL KETONE | 78-93-3 | EPA-SARA, JANK |
| METHYL ISOBUTYL KETONE | 108-10-1 | JANK |
| METHYL ISOCYANATE | 624-83-9 | EPA-HEN, EPA-SARA, JANK |
| METHYL METHACRYLATE | 80-62-6 | EPA-SARA |
| METRIBUZIN | 21087-64-9 | EPA-TRI, P65-PEND |
| MOLINATE | 2212-67-1 | EPA-TRI |
| MUSTARD GAS | 505-60-2 | ATSDR |
| N,N-DIMETHYLFORMAMIDE | 68-12-2 | JANK, NTP-R |
| N-ETHYL-N-NITROSOUREA | 759-73-9 | EPA-SARA |
| N-HEXANE | 110-54-3 | JANK |
| N-NITROSO-N-METHYLUREA | 684-93-5 | EPA-SARA, JANK |
| N-NITROSODIETHYLAMINE | 55-18-5 | EPA-SARA, JANK |
| N-NITROSOMORPHOLINE | 59-89-2 | EPA-SARA |
| NAPHTHALENE | 91-20-3 | EPA-HEN, EPA-SARA |
| NICKEL | 7440-02-0 | EPA-SARA |
| NICKEL COMPOUNDS | NDB000 | P65-MC |
| NITROFEN | 1836-75-5 | EPA-SARA, JANK |
| NITROFURANTOIN | 67-20-9 | NTP-R |
| NITROGEN DIOXIDE | 10102-44-0 | CAA-AQC |
| NITROUS OXIDE | 10024-97-2 | JANK |
| O-XYLENE | 95-47-6 | EPA-SARA, JANK |
| ORGANIC BROMINE COMPOUNDS | EDF-226 | P65-MC |
| ORGANOCHLORINE PESTICIDES | EDF-175 | P65-MC |
| P-XYLENE | 106-42-3 | EPA-SARA, JANK |
| PARATHION | 56-38-2 | EPA-SARA |
| PENTACHLOROPHENOL | 87-86-5 | ATSDR, EPA-SARA, OEHHA-CREL |
| PHENOL | 108-95-2 | EPA-SARA, JANK |
| PHTHALATES | EDF-150 | P65-MC |
| PM 10 | EDF-077 | P65-MC |
| PM 2.5 | EDF-213 | P65-MC |
| POLYCHLORINATED DIBENZO-P-DIOXINS | PCDD | P65-MC |
| POLYCHLORINATED TERPHENYLS | 61788-33-8 | JANK |
| POTASSIUM IODIDE | 7681-11-0 | JANK |
| POTASSIUM N-METHYLDITHIOCARBAMATE | 137-41-7 | EPA-TRI |
| PROPACHLOR | 1918-16-7 | EPA-TRI |
| PROPYLENE OXIDE | 75-56-9 | EPA-SARA |
| QUINTOZENE | 82-68-8 | EPA-SARA |
| RADIONUCLIDES | 1165 | P65-MC |
| RONNEL | 299-84-3 | JANK |
| SACCHARIN | 81-07-2 | EPA-SARA |
| SELENIUM | 7782-49-2 | EPA-SARA |
| SIMVASTATIN | 79902-63-9 | P65-PEND |
| SODIUM CHLORITE | 7758-19-2 | JANK |
| SODIUM DICAMBA | 1982-69-0 | EPA-TRI |
| SODIUM FLUORIDE | 7681-49-4 | JANK |
| SODIUM IODIDE | 7681-82-5 | JANK |
| SODIUM NITRITE | 7632-00-0 | EPA-TRI |
| SOLUBLE NICKEL COMPOUNDS | 7440-02-0(Sol) | P65-MC |
| STYRENE | 100-42-5 | EPA-SARA, JANK |
| STYRENE OXIDE | 96-09-3 | EPA-SARA, JANK |
| SULFUR DIOXIDE | 7446-09-5 | JANK |
| SULPROFOS | 35400-43-2 | EPA-TRI |
| TEBUTHIURON | 34014-18-1 | EPA-TRI |
| TERT-BUTYL ALCOHOL | 75-65-0 | JANK |
| TETRACHLOROETHYLENE | 127-18-4 | ATSDR, EPA-SARA |
| TETRAHYDROFURAN | 109-99-9 | JANK |
| THIABENDAZOLE | 148-79-8 | EPA-TRI, JANK |
| THIADIAZOLE, 2,2'-(METHYLENEDIIMINO)BIS, 1,3,4- | 26907-37-9 | JANK |
| THIOUREA | 62-56-6 | EPA-SARA, JANK |
| THIRAM | 137-26-8 | JANK |
| TOLUENESULFONAMIDE, O- | 88-19-7 | JANK |
| TRIBUTYLTIN COMPOUNDS | EDF-184 | P65-MC |
| TRICHLORFON | 52-68-6 | EPA-SARA, JANK |
| TRICHLOROETHYLENE | 79-01-6 | ATSDR, EPA-HEN, EPA-SARA, JANK |
| TRIETHYLENE GLYCOL | 112-27-6 | JANK |
| TRIETHYLENE GLYCOL DIMETHYL ETHER | 112-49-2 | JANK, NTP-R |
| TRIFLURALIN | 1582-09-8 | EPA-SARA, JANK |
| TRIS(2,3-DIBROMOPROPYL) PHOSPHATE | 126-72-7 | EPA-SARA |
| VINYL CHLORIDE | 75-01-4 | ATSDR, EPA-SARA, JANK |
| VISIBILITY REDUCING PARTICULATES | EDF-214 | P65-MC |
| VOLATILE ORGANIC COMPOUNDS | EDF-111 | P65-MC |
| WOOD PRESERVATIVES (CONTAINING ARSENIC & CHROMATE) | 1206 | P65-MC |
| XYLENE (MIXED ISOMERS) | 1330-20-7 | ATSDR, EPA-SARA, JANK |
| ZEARALENONE | 17924-92-4 | P65-PEND |
| ZINC | 7440-66-6 | EPA-SARA |
| ZINC SULFATE | 7733-02-0 | JANK |
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