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HEALTH EFFECTS|Reproductive Toxicants
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Reproductive Toxicants
Exposure to chemical substances can cause adverse effects on the male and female reproductive systems. Reproductive toxicity may be expressed as alterations in sexual behavior, decreases in fertility, or loss of the fetus during pregnancy. A reproductive toxicant may interfere with the sexual functioning or reproductive ability of exposed individuals from puberty throughout adulthood. Toxicants that target the female reproductive system can cause a wide variety of adverse effects. Changes
in sexual behavior, onset of puberty, cyclicity, fertility, gestation time, pregnancy outcome, and lactation as well as premature menopause are among the potential manifestations of female reproductive toxicity: all can disrupt a womans ability to successfully reproduce. Exposure to lead, for example, can result in menstrual disorders and infertility. The toxicants carbon disulfide, mercury, and polychlorinated biphenyls (PBCs) have been shown to cause irregularities in the menstrual cycle. Toxicants that target the male reproductive system can affect sperm count or shape, alter sexual behavior, and/or increase infertility. Carbon disulfide and the pesticides chlordecone (kepone), ethylene dibromide (EDB), and dibromochloropropane (DBCP) are examples of chemicals known to disrupt male reproductive health.
References used to compile the list of Reproductive Toxicants
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Recognized Reproductive Toxicants
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| Chemical Name |
CAS Registry Number (or EDF Substance ID) |
Reference(s) |
| (1,2-BENZENEDICARBOXYLATO(2-))DIOXOTRILEAD | 69011-06-9 | P65-MC |
| 1,2-DIBROMO-3-CHLOROPROPANE (DBCP) | 96-12-8 | P65 |
| 1,2-DIBROMOETHANE | 106-93-4 | P65 |
| 1,3-BUTADIENE | 106-99-0 | P65 |
| 2,3-DINITROTOLUENE | 602-01-7 | P65-MC |
| 2,4-DB | 94-82-6 | P65 |
| 2,4-DINITROTOLUENE | 121-14-2 | P65 |
| 2,5-DINITROTOLUENE | 619-15-8 | P65-MC |
| 2,6-DINITROTOLUENE | 606-20-2 | P65 |
| 3,4-DINITROTOLUENE | 610-39-9 | P65-MC |
| ACETYLSALICYLIC ACID | 50-78-2 | P65 |
| ADRIAMYCIN | 23214-92-8 | P65 |
| ALKYL LEAD COMPOUNDS | EDF-171 | P65-MC |
| AMINOPTERIN | 54-62-6 | P65 |
| AMIODARONE HYDROCHLORIDE | 19774-82-4 | P65 |
| ANABOLIC STEROIDS | EDF-006 | P65 |
| BENOMYL | 17804-35-2 | P65 |
| BENZENE | 71-43-2 | P65 |
| BIS(2-ETHYLHEXYL)PHTHALATE | 117-81-7 | P65 |
| BROMACIL LITHIUM SALT (2,4(H,3H)-PYRIMIDINEDIONE, ETHYL-3 (1-METHYLPROPYL), LITHIUM SALT) | 53404-19-6 | P65 |
| CADMIUM | 7440-43-9 | P65 |
| CARBON DISULFIDE | 75-15-0 | P65 |
| CHLORSULFURON | 64902-72-3 | P65 |
| CHROMIUM LEAD SILICATE | 11113-70-5 | P65-MC |
| CIDOFOVIR | 113852-37-2 | P65 |
| CLOBETASOL PROPIONATE | 25122-46-7 | P65 |
| COCAINE | 50-36-2 | P65 |
| COLCHICINE | 64-86-8 | P65 |
| CYCLO-DI-:-OXO(:-PHTHALATO)TRILEAD | 17976-43-1 | P65-MC |
| CYCLOPHOSPHAMIDE | 50-18-0 | P65 |
| CYCLOPHOSPHAMIDE (HYDRATED) | 6055-19-2 | P65 |
| DDT | 50-29-3 | P65 |
| DIFLUNISAL | 22494-42-4 | P65 |
| DINITROBENZENE | 25154-54-5 | P65-MC |
| DINITROBUTYL PHENOL | 88-85-7 | P65 |
| DINITROTOLUENE (MIXED ISOMERS) | 25321-14-6 | P65 |
| EPICHLOROHYDRIN | 106-89-8 | P65 |
| ETHYLENE GLYCOL MONOETHYL ETHER | 110-80-5 | P65 |
| ETHYLENE GLYCOL MONOETHYL ETHER ACETATE | 111-15-9 | P65 |
| ETHYLENE GLYCOL MONOMETHYL ETHER | 109-86-4 | P65 |
| ETHYLENE GLYCOL MONOMETHYL ETHER ACETATE | 110-49-6 | P65 |
| ETHYLENE OXIDE | 75-21-8 | P65 |
| ETODOLAC | 41340-25-4 | P65 |
| FLUNISOLIDE | 3385-03-3 | P65 |
| FLUOROACETIC ACID, SODIUM SALT | 62-74-8 | P65 |
| FLURBIPROFEN | 5104-49-4 | P65 |
| GANCICLOVIR SODIUM | 82410-32-0 | P65 |
| GEMFIBORZIL | 25812-30-0 | P65 |
| GOSERELIN ACETATE | 65807-02-5 | P65 |
| HALOPERIDOL | 52-86-8 | P65 |
| HEXAMETHYLPHOSPHORAMIDE | 680-31-9 | P65 |
| HYDRAMETHYLNON | 67485-29-4 | P65 |
| IDARUBICIN HYDROCHLORIDE | 57852-57-0 | P65 |
| INORGANIC LEAD COMPOUNDS | 1128 | P65-MC |
| LEAD | 7439-92-1 | P65 |
| LEAD (ALKYL 4+) (SOLNR LEAD ALKYLS) | EDF-199 | P65-MC |
| LEAD ACETATE | 301-04-2 | P65-MC |
| LEAD ARSENATE | 7784-40-9 | P65-MC |
| LEAD ARSENITE | 10031-13-7 | P65-MC |
| LEAD CHLORIDE | 7758-95-4 | P65-MC |
| LEAD CHROMATE | 7758-97-6 | P65-MC |
| LEAD CHROMATE OXIDE | 18454-12-1 | P65-MC |
| LEAD COMPOUNDS | LCT000 | P65 |
| LEAD DIOXIDE | 1309-60-0 | P65-MC |
| LEAD FLUOBORATE | 13814-96-5 | P65-MC |
| LEAD FLUORIDE | 7783-46-2 | P65-MC |
| LEAD II ARSENATE | 7645-25-2 | P65-MC |
| LEAD IODIDE | 10101-63-0 | P65-MC |
| LEAD NITRATE | 10099-74-8 | P65-MC |
| LEAD PHOSPHATE | 7446-27-7 | P65-MC |
| LEAD SILICATE | 11120-22-2 | P65-MC |
| LEAD STEARATE | 7428-48-0 | P65-MC |
| LEAD SUBACETATE | 1335-32-6 | P65-MC |
| LEAD SULFATE | 7446-14-2 | P65-MC |
| LEAD SULFIDE | 1314-87-0 | P65-MC |
| LEAD THIOCYANATE | 592-87-0 | P65-MC |
| LEAD(II) OXIDE | 1317-36-8 | P65-MC |
| LEAD-MOLYBDENUM CHROMATE | 12709-98-7 | P65-MC |
| LEUPROLIDE ACETATE | 74381-53-6 | P65 |
| LEVONORGESTREL IMPLANTS | 797-63-7 | P65 |
| M-DINITROBENZENE | 99-65-0 | P65 |
| MELAMINE, HEXAMETHYL- | 645-05-6 | P65 |
| MYCLOBUTANIL | 88671-89-0 | P65 |
| NIFEDIPINE | 21829-25-4 | P65 |
| NITROFURANTOIN | 67-20-9 | P65 |
| O,P'-DDT | 789-02-6 | P65 |
| O-DINITROBENZENE | 528-29-0 | P65 |
| ORGANIC LEAD COMPOUNDS | EDF-230 | P65-MC |
| OXYDEMETON METHYL | 301-12-2 | P65 |
| P-DINITROBENZENE | 100-25-4 | P65 |
| PACLITAXEL | 33069-62-4 | P65 |
| PIMOZIDE | 2062-78-4 | P65 |
| QUIZALOFOP-ETHYL | 76578-14-8 | P65 |
| RIBAVIRIN | 36791-04-5 | P65 |
| RIFAMPICIN | 13292-46-1 | P65 |
| SALICYLAZOSULFAPYRIDINE | 599-79-1 | P65 |
| STREPTOZOTOCIN | 18883-66-4 | P65 |
| SULINDAC | 38194-50-2 | P65 |
| TECHNICAL GRADE 2,4 & 2,6 DINITROTOLUENE | EDF-210 | P65-MC |
| TETRAETHYLLEAD | 78-00-2 | P65-MC |
| TETRAMETHYL LEAD | 75-74-1 | P65-MC |
| THIOPHANATE-METHYL | 23564-05-8 | P65 |
| TOBACCO SMOKE (PRIMARY) | EDF-073 | P65 |
| TRIADIMEFON | 43121-43-3 | P65 |
| URACIL MUSTARD | 66-75-1 | P65 |
| ZILEUTON | 111406-87-2 | P65 |
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